No problems here on Win7 x64. In fact, some programs start noeticeably faster. I had COMPLUS_useLegacyJit set to 1, COMPLUS_JitMinOpts 1, useLegacyJit 1, all from before, and the installation added UseRyuJIT=1 and it left it like that.
As discussed here.
I'm not touching anything as long as it works.
Oh, and I'm using .Net 4.7 slim from repacks.net.